Drug interactions
Isoniazid + Lansoprazole
Severity: Minor
Isoniazid and Lansoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid inhibits CYP2C19 and may raise lansoprazole exposure modestly. Lansoprazole has a wide safety margin, so the clinical effect is usually small.
What this interaction means in plain words
Isoniazid and Lansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isoniazid belongs to Anti Bacterial; Lansoprazole belongs to Gastrointestinal Tract.
Why it happens
Isoniazid inhibits CYP2C19-mediated metabolism of lansoprazole.
What to do
No dose adjustment is usually needed; watch for increased PPI adverse effects such as headache or diarrhea during prolonged co-therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Isoniazid
Frequently asked questions
Can I take Isoniazid with Lansoprazole?
MediHelp rates the interaction as minor. Isoniazid and Lansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid inhibits CYP2C19 and may raise lansoprazole exposure modestly. Lansoprazole has a wide safety margin, so the clinical effect is usually small.
How serious is the interaction between Isoniazid and Lansoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; watch for increased PPI adverse effects such as headache or diarrhea during prolonged co-therapy.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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