Drug interactions
Isoniazid + Lofepramine
Severity: Minor
Isoniazid and Lofepramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid has weak MAO-inhibiting activity, and adding a tricyclic antidepressant such as lofepramine could theoretically raise monoamine effects. Reports of clinically important reactions are scarce.
What this interaction means in plain words
Isoniazid and Lofepramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak MAO inhibition by isoniazid may add to the monoamine reuptake inhibition of lofepramine.
What to do
Monitor for signs of serotonergic or adrenergic excess such as agitation, tremor and sweating. Reduce the lofepramine dose if symptoms appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Frequently asked questions
Can I take Isoniazid with Lofepramine?
MediHelp rates the interaction as minor. Isoniazid and Lofepramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid has weak MAO-inhibiting activity, and adding a tricyclic antidepressant such as lofepramine could theoretically raise monoamine effects. Reports of clinically important reactions are scarce.
How serious is the interaction between Isoniazid and Lofepramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonergic or adrenergic excess such as agitation, tremor and sweating. Reduce the lofepramine dose if symptoms appear.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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