Drug interactions
Isoniazid + Lorcaserin
Severity: Moderate
Isoniazid and Lorcaserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid has weak monoamine oxidase inhibitory activity, and lorcaserin is a serotonin 5-HT2C agonist. Together they could theoretically contribute to serotonin toxicity. Clinical reports are lacking.
What this interaction means in plain words
Isoniazid and Lorcaserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive serotonergic effect from weak MAO inhibition by isoniazid combined with 5-HT2C agonism.
What to do
Monitor for agitation, tremor, hyperthermia, clonus and autonomic instability. Stop lorcaserin if symptoms of serotonin toxicity occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Isoniazid and Lorcaserin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Isoniazid
Frequently asked questions
Can I take Isoniazid with Lorcaserin?
MediHelp rates the interaction as moderate. Isoniazid and Lorcaserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoniazid has weak monoamine oxidase inhibitory activity, and lorcaserin is a serotonin 5-HT2C agonist. Together they could theoretically contribute to serotonin toxicity. Clinical reports are lacking.
How serious is the interaction between Isoniazid and Lorcaserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperthermia, clonus and autonomic instability. Stop lorcaserin if symptoms of serotonin toxicity occur.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
