Drug interactions
Isoniazid + Lumefantrine
Severity: Minor
Isoniazid and Lumefantrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid is a weak CYP3A4 inhibitor and could slightly raise lumefantrine concentrations. Lumefantrine can prolong the QT interval, but a meaningful effect from isoniazid is not established.
What this interaction means in plain words
Isoniazid and Lumefantrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak CYP3A4 inhibition reducing lumefantrine metabolism.
What to do
No dose change is required. Check for other QT-prolonging drugs and electrolyte abnormalities in patients on both agents.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Frequently asked questions
Can I take Isoniazid with Lumefantrine?
MediHelp rates the interaction as minor. Isoniazid and Lumefantrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid is a weak CYP3A4 inhibitor and could slightly raise lumefantrine concentrations. Lumefantrine can prolong the QT interval, but a meaningful effect from isoniazid is not established.
How serious is the interaction between Isoniazid and Lumefantrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is required. Check for other QT-prolonging drugs and electrolyte abnormalities in patients on both agents.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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