Drug interactions
Isoniazid + Metformin-sitagliptin
Severity: Minor
Isoniazid and Metformin-sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid can impair glucose tolerance and make glycemic control more difficult in patients with diabetes. The effect is variable and usually modest.
What this interaction means in plain words
Isoniazid and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isoniazid belongs to Anti Bacterial; Metformin-sitagliptin belongs to Endocrine.
Why it happens
The mechanism is not well established; isoniazid may interfere with carbohydrate metabolism, opposing antidiabetic therapy.
What to do
Monitor blood glucose during isoniazid therapy and adjust antidiabetic treatment if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-sitagliptin
Other interactions of Isoniazid
Frequently asked questions
Can I take Isoniazid with Metformin-sitagliptin?
MediHelp rates the interaction as minor. Isoniazid and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid can impair glucose tolerance and make glycemic control more difficult in patients with diabetes. The effect is variable and usually modest.
How serious is the interaction between Isoniazid and Metformin-sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during isoniazid therapy and adjust antidiabetic treatment if control worsens.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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