Drug interactions
Isoniazid + Midazolam intranasal
Severity: Moderate
Isoniazid and Midazolam intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midazolam is a sensitive CYP3A4 substrate, and inhibitors prolong sedation and can cause respiratory depression. Isoniazid is only a weak inhibitor, so the effect is likely modest, but it may be noticeable after a single intranasal dose.
What this interaction means in plain words
Isoniazid and Midazolam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Isoniazid weakly inhibits CYP3A4, which may slow midazolam clearance.
What to do
Monitor sedation level and respiratory status after dosing. Avoid repeat doses sooner than usual.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Frequently asked questions
Can I take Isoniazid with Midazolam intranasal?
MediHelp rates the interaction as moderate. Isoniazid and Midazolam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midazolam is a sensitive CYP3A4 substrate, and inhibitors prolong sedation and can cause respiratory depression. Isoniazid is only a weak inhibitor, so the effect is likely modest, but it may be noticeable after a single intranasal dose.
How serious is the interaction between Isoniazid and Midazolam intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and respiratory status after dosing. Avoid repeat doses sooner than usual.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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