Drug interactions
Isoniazid + Mipomersen
Severity: Major
Isoniazid and Mipomersen: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both isoniazid and mipomersen can cause liver injury, including transaminase elevations. Using them together may increase hepatotoxicity risk. Mipomersen carries a boxed warning for hepatotoxicity.
What this interaction means in plain words
Isoniazid and Mipomersen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive hepatotoxicity through different mechanisms.
What to do
Avoid the combination where possible. If needed, monitor ALT, AST and bilirubin closely, and stop either agent if significant elevations occur.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Isoniazid
Frequently asked questions
Can I take Isoniazid with Mipomersen?
MediHelp rates the interaction as major. Isoniazid and Mipomersen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both isoniazid and mipomersen can cause liver injury, including transaminase elevations. Using them together may increase hepatotoxicity risk. Mipomersen carries a boxed warning for hepatotoxicity.
How serious is the interaction between Isoniazid and Mipomersen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If needed, monitor ALT, AST and bilirubin closely, and stop either agent if significant elevations occur.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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