Drug interactions
Isoniazid + Nirogacestat
Severity: Moderate
Isoniazid and Nirogacestat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nirogacestat is cleared mainly by CYP3A4, and increased exposure can worsen diarrhea, hepatotoxicity and ovarian toxicity. Isoniazid may modestly raise levels.
What this interaction means in plain words
Isoniazid and Nirogacestat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoniazid belongs to Anti Bacterial; Nirogacestat belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by isoniazid may reduce nirogacestat clearance.
What to do
Monitor liver enzymes and gastrointestinal tolerance. Reduce or interrupt nirogacestat if adverse effects become significant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Nirogacestat
Frequently asked questions
Can I take Isoniazid with Nirogacestat?
MediHelp rates the interaction as moderate. Isoniazid and Nirogacestat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nirogacestat is cleared mainly by CYP3A4, and increased exposure can worsen diarrhea, hepatotoxicity and ovarian toxicity. Isoniazid may modestly raise levels.
How serious is the interaction between Isoniazid and Nirogacestat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and gastrointestinal tolerance. Reduce or interrupt nirogacestat if adverse effects become significant.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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