Drug interactions
Isoniazid + Nitrendipine
Severity: Minor
Isoniazid and Nitrendipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitrendipine is a CYP3A4 substrate with high first-pass metabolism, so inhibition of the enzyme can raise its levels. Isoniazid is only a weak inhibitor, so any increase is likely small, though hypotension and edema are possible.
What this interaction means in plain words
Isoniazid and Nitrendipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 inhibition by isoniazid may reduce first-pass metabolism of nitrendipine.
What to do
Monitor blood pressure and heart rate when starting isoniazid. Reduce the nitrendipine dose if excessive hypotension or peripheral edema develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Frequently asked questions
Can I take Isoniazid with Nitrendipine?
MediHelp rates the interaction as minor. Isoniazid and Nitrendipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nitrendipine is a CYP3A4 substrate with high first-pass metabolism, so inhibition of the enzyme can raise its levels. Isoniazid is only a weak inhibitor, so any increase is likely small, though hypotension and edema are possible.
How serious is the interaction between Isoniazid and Nitrendipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting isoniazid. Reduce the nitrendipine dose if excessive hypotension or peripheral edema develops.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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