Drug interactions
Isoniazid + Olaparib
Severity: Moderate
Isoniazid and Olaparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olaparib is metabolized by CYP3A4, and inhibitors can increase exposure and the risk of anemia, nausea and other toxicity. Isoniazid is only a weak inhibitor, so the effect is likely modest.
What this interaction means in plain words
Isoniazid and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoniazid belongs to Anti Bacterial; Olaparib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by isoniazid may raise olaparib concentrations.
What to do
Monitor blood counts and tolerability. Reduce the olaparib dose if hematologic or other toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Olaparib
- Amiodarone + Olaparib Major
- Amobarbital + Olaparib Major
- Apalutamide + Olaparib Major
- Aprepitant + Olaparib Major
- Azathioprine + Olaparib Major
- Carbamazepine + Olaparib Major
Frequently asked questions
Can I take Isoniazid with Olaparib?
MediHelp rates the interaction as moderate. Isoniazid and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olaparib is metabolized by CYP3A4, and inhibitors can increase exposure and the risk of anemia, nausea and other toxicity. Isoniazid is only a weak inhibitor, so the effect is likely modest.
How serious is the interaction between Isoniazid and Olaparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and tolerability. Reduce the olaparib dose if hematologic or other toxicity develops.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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