Drug interactions
Isoniazid + Paclitaxel protein bound
Severity: Moderate
Isoniazid and Paclitaxel protein bound: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paclitaxel is partly metabolized by CYP3A4 and CYP2C8, and isoniazid is only a weak CYP3A4 inhibitor. A meaningful rise in paclitaxel exposure is unlikely, but both agents can cause peripheral neuropathy.
What this interaction means in plain words
Isoniazid and Paclitaxel protein bound can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Weak CYP3A4 inhibition by isoniazid; additive neurotoxicity pharmacodynamically.
What to do
Monitor for peripheral neuropathy and myelosuppression. Consider pyridoxine supplementation for isoniazid and reduce the paclitaxel dose if neuropathy worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Frequently asked questions
Can I take Isoniazid with Paclitaxel protein bound?
MediHelp rates the interaction as moderate. Isoniazid and Paclitaxel protein bound can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paclitaxel is partly metabolized by CYP3A4 and CYP2C8, and isoniazid is only a weak CYP3A4 inhibitor. A meaningful rise in paclitaxel exposure is unlikely, but both agents can cause peripheral neuropathy.
How serious is the interaction between Isoniazid and Paclitaxel protein bound?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for peripheral neuropathy and myelosuppression. Consider pyridoxine supplementation for isoniazid and reduce the paclitaxel dose if neuropathy worsens.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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