Drug interactions
Isoniazid + Ponatinib
Severity: Moderate
Isoniazid and Ponatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ponatinib is metabolized by CYP3A4 and causes arterial occlusion, heart failure and hepatotoxicity in a dose-related way. Isoniazid may modestly raise exposure and adds hepatotoxic potential.
What this interaction means in plain words
Isoniazid and Ponatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoniazid belongs to Anti Bacterial; Ponatinib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by isoniazid may raise ponatinib levels, with overlapping hepatotoxicity.
What to do
Monitor liver tests and cardiovascular status, and consider a lower ponatinib dose if the combination is necessary. Interrupt ponatinib for serious adverse events.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Ponatinib
Frequently asked questions
Can I take Isoniazid with Ponatinib?
MediHelp rates the interaction as moderate. Isoniazid and Ponatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ponatinib is metabolized by CYP3A4 and causes arterial occlusion, heart failure and hepatotoxicity in a dose-related way. Isoniazid may modestly raise exposure and adds hepatotoxic potential.
How serious is the interaction between Isoniazid and Ponatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver tests and cardiovascular status, and consider a lower ponatinib dose if the combination is necessary. Interrupt ponatinib for serious adverse events.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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