Drug interactions
Isoniazid + Romidepsin
Severity: Minor
Isoniazid and Romidepsin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Romidepsin is metabolized mainly by CYP3A4, and isoniazid is a weak inhibitor, so any rise in exposure is likely small. Romidepsin can prolong QT and cause myelosuppression, so extra vigilance is reasonable.
What this interaction means in plain words
Isoniazid and Romidepsin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak CYP3A4 inhibition by isoniazid reducing romidepsin metabolism.
What to do
No dose change is needed. Monitor blood counts, electrolytes and ECG as per romidepsin practice.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Frequently asked questions
Can I take Isoniazid with Romidepsin?
MediHelp rates the interaction as minor. Isoniazid and Romidepsin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Romidepsin is metabolized mainly by CYP3A4, and isoniazid is a weak inhibitor, so any rise in exposure is likely small. Romidepsin can prolong QT and cause myelosuppression, so extra vigilance is reasonable.
How serious is the interaction between Isoniazid and Romidepsin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor blood counts, electrolytes and ECG as per romidepsin practice.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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