Drug interactions
Isoniazid + Same
Severity: Moderate
Isoniazid and Same: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SAMe (S-adenosylmethionine) may increase serotonergic activity, and isoniazid has weak MAO inhibiting properties. The combination could theoretically contribute to serotonin toxicity, though documented cases are scarce.
What this interaction means in plain words
Isoniazid and Same can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Theoretical additive serotonergic effects from weak MAO inhibition and increased methyl donor-driven monoamine synthesis.
What to do
Avoid concurrent use where possible. If combined, monitor for agitation, tremor, clonus and hyperthermia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Frequently asked questions
Can I take Isoniazid with Same?
MediHelp rates the interaction as moderate. Isoniazid and Same can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SAMe (S-adenosylmethionine) may increase serotonergic activity, and isoniazid has weak MAO inhibiting properties. The combination could theoretically contribute to serotonin toxicity, though documented cases are scarce.
How serious is the interaction between Isoniazid and Same?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible. If combined, monitor for agitation, tremor, clonus and hyperthermia.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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