Drug interactions
Isoniazid + Selegiline transdermal
Severity: Moderate
Isoniazid and Selegiline transdermal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Transdermal selegiline is an MAO inhibitor used for depression, and isoniazid has weak MAO-inhibiting activity, so additive effects could cause hypertensive or serotonergic reactions. Documented cases are limited, but the potential for harm with MAO inhibitors justifies caution.
What this interaction means in plain words
Isoniazid and Selegiline transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive MAO inhibition from selegiline and the weak MAO-inhibiting activity of isoniazid.
What to do
Monitor blood pressure and for features of serotonin syndrome, and follow the labeled dietary and drug precautions for selegiline. Consider an alternative antituberculosis regimen if significant symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Frequently asked questions
Can I take Isoniazid with Selegiline transdermal?
MediHelp rates the interaction as moderate. Isoniazid and Selegiline transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Transdermal selegiline is an MAO inhibitor used for depression, and isoniazid has weak MAO-inhibiting activity, so additive effects could cause hypertensive or serotonergic reactions. Documented cases are limited, but the potential for harm with MAO inhibitors justifies caution.
How serious is the interaction between Isoniazid and Selegiline transdermal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for features of serotonin syndrome, and follow the labeled dietary and drug precautions for selegiline. Consider an alternative antituberculosis regimen if significant symptoms develop.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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