Drug interactions
Isoniazid + Selumetinib
Severity: Moderate
Isoniazid and Selumetinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selumetinib is metabolized substantially by CYP3A4, so inhibitors can raise its exposure. Isoniazid is only a weak, inconsistent CYP3A inhibitor, so the effect is likely small. Increased selumetinib toxicity such as gastrointestinal effects or rash is possible.
What this interaction means in plain words
Isoniazid and Selumetinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoniazid belongs to Anti Bacterial; Selumetinib belongs to Oncology.
Why it happens
Isoniazid may weakly inhibit CYP3A4, reducing selumetinib metabolism.
What to do
Monitor for selumetinib adverse effects. Reduce the dose per labeling if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Selumetinib
Frequently asked questions
Can I take Isoniazid with Selumetinib?
MediHelp rates the interaction as moderate. Isoniazid and Selumetinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selumetinib is metabolized substantially by CYP3A4, so inhibitors can raise its exposure. Isoniazid is only a weak, inconsistent CYP3A inhibitor, so the effect is likely small. Increased selumetinib toxicity such as gastrointestinal effects or rash is possible.
How serious is the interaction between Isoniazid and Selumetinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for selumetinib adverse effects. Reduce the dose per labeling if toxicity occurs.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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