Drug interactions
Isoniazid + Sodium citrate / citric acid
Severity: Minor
Isoniazid and Sodium citrate / citric acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Citrate-based alkalinizing agents might lower the absorption of oral isoniazid by raising gastric pH. The evidence is limited and extrapolated from antacid data.
What this interaction means in plain words
Isoniazid and Sodium citrate / citric acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible reduction in isoniazid absorption through altered gastric pH.
What to do
Separate administration by about 2 hours, giving isoniazid first. No other change is generally needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Frequently asked questions
Can I take Isoniazid with Sodium citrate / citric acid?
MediHelp rates the interaction as minor. Isoniazid and Sodium citrate / citric acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Citrate-based alkalinizing agents might lower the absorption of oral isoniazid by raising gastric pH. The evidence is limited and extrapolated from antacid data.
How serious is the interaction between Isoniazid and Sodium citrate / citric acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate administration by about 2 hours, giving isoniazid first. No other change is generally needed.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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