Drug interactions
Isoniazid + Tofacitinib
Severity: Minor
Isoniazid and Tofacitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid is a weak inhibitor of CYP3A4 and other enzymes, so an effect on tofacitinib exposure is unlikely to be significant. It is commonly given alongside tofacitinib as latent tuberculosis prophylaxis.
What this interaction means in plain words
Isoniazid and Tofacitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isoniazid belongs to Anti Bacterial; Tofacitinib belongs to Musculoskeletal.
Why it happens
Weak, clinically unproven CYP3A4 inhibition.
What to do
No dose adjustment is generally needed; monitor liver enzymes as part of routine care with both drugs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Other interactions of Isoniazid
Frequently asked questions
Can I take Isoniazid with Tofacitinib?
MediHelp rates the interaction as minor. Isoniazid and Tofacitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid is a weak inhibitor of CYP3A4 and other enzymes, so an effect on tofacitinib exposure is unlikely to be significant. It is commonly given alongside tofacitinib as latent tuberculosis prophylaxis.
How serious is the interaction between Isoniazid and Tofacitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed; monitor liver enzymes as part of routine care with both drugs.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
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