Drug interactions
Isoniazid + Triazolam
Severity: Moderate
Isoniazid and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid has been reported to raise exposure to some benzodiazepines metabolized by oxidation, and triazolam is a sensitive CYP3A4 substrate. This may lead to stronger or longer sedation and psychomotor impairment.
What this interaction means in plain words
Isoniazid and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Isoniazid inhibits CYP3A4 and other oxidative enzymes, reducing triazolam clearance.
What to do
Monitor for excess sedation and consider a lower triazolam dose during isoniazid therapy. Counsel patients about next-day impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Frequently asked questions
Can I take Isoniazid with Triazolam?
MediHelp rates the interaction as moderate. Isoniazid and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoniazid has been reported to raise exposure to some benzodiazepines metabolized by oxidation, and triazolam is a sensitive CYP3A4 substrate. This may lead to stronger or longer sedation and psychomotor impairment.
How serious is the interaction between Isoniazid and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and consider a lower triazolam dose during isoniazid therapy. Counsel patients about next-day impairment.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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