Drug interactions
Isoniazid + Umeclidinium bromide / vilanterol inhaled
Severity: Minor
Isoniazid and Umeclidinium bromide / vilanterol inhaled: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol is a CYP3A4 substrate, and inhibitors can increase its systemic exposure, which may cause tachycardia, tremor and hypokalemia. Because inhaled doses are low and isoniazid is only a weak CYP3A4 inhibitor, the effect is likely small.
What this interaction means in plain words
Isoniazid and Umeclidinium bromide / vilanterol inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Isoniazid inhibits CYP3A4, which may slightly increase systemic vilanterol exposure.
What to do
No routine adjustment is needed. Monitor heart rate, tremor and potassium if the patient has cardiovascular risk factors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Frequently asked questions
Can I take Isoniazid with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as minor. Isoniazid and Umeclidinium bromide / vilanterol inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vilanterol is a CYP3A4 substrate, and inhibitors can increase its systemic exposure, which may cause tachycardia, tremor and hypokalemia. Because inhaled doses are low and isoniazid is only a weak CYP3A4 inhibitor, the effect is likely small.
How serious is the interaction between Isoniazid and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor heart rate, tremor and potassium if the patient has cardiovascular risk factors.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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