Drug interactions
Isoniazid + Vilanterol / fluticasone furoate inhaled
Severity: Minor
Isoniazid and Vilanterol / fluticasone furoate inhaled: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both components of this inhaler are CYP3A4 substrates, so isoniazid could modestly increase systemic exposure. Increased corticosteroid or beta-agonist effects are possible but unlikely with the weak inhibition from isoniazid.
What this interaction means in plain words
Isoniazid and Vilanterol / fluticasone furoate inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Isoniazid weakly inhibits CYP3A4-mediated metabolism of fluticasone furoate and vilanterol.
What to do
No dose adjustment is usually required; monitor for tachycardia, tremor, hypokalemia and signs of systemic corticosteroid excess during prolonged therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Frequently asked questions
Can I take Isoniazid with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as minor. Isoniazid and Vilanterol / fluticasone furoate inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both components of this inhaler are CYP3A4 substrates, so isoniazid could modestly increase systemic exposure. Increased corticosteroid or beta-agonist effects are possible but unlikely with the weak inhibition from isoniazid.
How serious is the interaction between Isoniazid and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually required; monitor for tachycardia, tremor, hypokalemia and signs of systemic corticosteroid excess during prolonged therapy.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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