Drug interactions
Isoniazid + Vorapaxar
Severity: Moderate
Isoniazid and Vorapaxar: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorapaxar is metabolized by CYP3A4, and strong inhibitors are avoided because of bleeding risk. Isoniazid is only a weak inhibitor, so any increase is likely small. Bleeding vigilance is still reasonable.
What this interaction means in plain words
Isoniazid and Vorapaxar can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Isoniazid may weakly inhibit CYP3A4, increasing vorapaxar exposure.
What to do
Monitor for bleeding signs and review need for dual antiplatelet therapy. Consider an alternative antiplatelet if bleeding risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Isoniazid and Vorapaxar, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Isoniazid
Frequently asked questions
Can I take Isoniazid with Vorapaxar?
MediHelp rates the interaction as moderate. Isoniazid and Vorapaxar can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vorapaxar is metabolized by CYP3A4, and strong inhibitors are avoided because of bleeding risk. Isoniazid is only a weak inhibitor, so any increase is likely small. Bleeding vigilance is still reasonable.
How serious is the interaction between Isoniazid and Vorapaxar?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding signs and review need for dual antiplatelet therapy. Consider an alternative antiplatelet if bleeding risk is high.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
