Drug interactions
Isoniazid + Zaleplon
Severity: Minor
Isoniazid and Zaleplon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid is a weak inhibitor of CYP3A4, and zaleplon is metabolised mainly by aldehyde oxidase with a smaller CYP3A4 contribution. Any increase in zaleplon exposure is expected to be small, though some added sedation is possible.
What this interaction means in plain words
Isoniazid and Zaleplon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isoniazid belongs to Anti Bacterial; Zaleplon belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by isoniazid may slightly reduce zaleplon clearance.
What to do
No dose change is normally needed. Advise patients to watch for excess sedation or next-day impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Other interactions of Zaleplon
- Calcium / magnesium / potassium / sodium oxybates + Zaleplon Contraindicated
- Sodium oxybate + Zaleplon Contraindicated
- Brexanolone + Zaleplon Major
- Buprenorphine long-acting + Zaleplon Major
- Buprenorphine subdermal implant + Zaleplon Major
- Buprenorphine transdermal + Zaleplon Major
Frequently asked questions
Can I take Isoniazid with Zaleplon?
MediHelp rates the interaction as minor. Isoniazid and Zaleplon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid is a weak inhibitor of CYP3A4, and zaleplon is metabolised mainly by aldehyde oxidase with a smaller CYP3A4 contribution. Any increase in zaleplon exposure is expected to be small, though some added sedation is possible.
How serious is the interaction between Isoniazid and Zaleplon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is normally needed. Advise patients to watch for excess sedation or next-day impairment.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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