Drug interactions
Isradipine + Lithium
Severity: Minor
Isradipine and Lithium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium channel blockers have been reported to cause neurotoxicity with lithium in some cases, mostly with verapamil and diltiazem. Isradipine is a dihydropyridine with less supporting evidence, and a QT effect is not an established concern. The interaction is probably of limited significance.
What this interaction means in plain words
Isradipine and Lithium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Not well established; possible pharmacodynamic effects on neuronal calcium handling.
What to do
Be aware of the possibility and ask the patient to report tremor, confusion, ataxia or palpitations. Check lithium levels if neurological symptoms appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Frequently asked questions
Can I take Isradipine with Lithium?
MediHelp rates the interaction as minor. Isradipine and Lithium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium channel blockers have been reported to cause neurotoxicity with lithium in some cases, mostly with verapamil and diltiazem. Isradipine is a dihydropyridine with less supporting evidence, and a QT effect is not an established concern. The interaction is probably of limited significance.
How serious is the interaction between Isradipine and Lithium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Be aware of the possibility and ask the patient to report tremor, confusion, ataxia or palpitations. Check lithium levels if neurological symptoms appear.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
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