Drug interactions
Japanese encephalitis virus vaccine + Methotrexate
Severity: Moderate
Japanese encephalitis virus vaccine and Methotrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methotrexate may reduce the antibody response to the inactivated Japanese encephalitis vaccine. Travelers may therefore have less reliable protection.
What this interaction means in plain words
Japanese encephalitis virus vaccine and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Methotrexate suppresses lymphocyte proliferation and humoral responses.
What to do
Vaccinate well before travel and consider checking neutralizing antibody titers. Reinforce mosquito-bite avoidance measures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Frequently asked questions
Can I take Japanese encephalitis virus vaccine with Methotrexate?
MediHelp rates the interaction as moderate. Japanese encephalitis virus vaccine and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methotrexate may reduce the antibody response to the inactivated Japanese encephalitis vaccine. Travelers may therefore have less reliable protection.
How serious is the interaction between Japanese encephalitis virus vaccine and Methotrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate well before travel and consider checking neutralizing antibody titers. Reinforce mosquito-bite avoidance measures.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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