Drug interactions
Ketamine + Lofepramine
Severity: Moderate
Ketamine and Lofepramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine is a tricyclic antidepressant with sedative and mild anticholinergic properties. With ketamine it may increase sedation, and tricyclics can potentiate the sympathomimetic cardiovascular effects of ketamine.
What this interaction means in plain words
Ketamine and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, with possible pharmacodynamic enhancement of sympathetic effects.
What to do
Monitor sedation, heart rate and blood pressure when ketamine is used. Use lower ketamine doses where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketamine
Frequently asked questions
Can I take Ketamine with Lofepramine?
MediHelp rates the interaction as moderate. Ketamine and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofepramine is a tricyclic antidepressant with sedative and mild anticholinergic properties. With ketamine it may increase sedation, and tricyclics can potentiate the sympathomimetic cardiovascular effects of ketamine.
How serious is the interaction between Ketamine and Lofepramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, heart rate and blood pressure when ketamine is used. Use lower ketamine doses where possible.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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