Drug interactions
Ketamine + Lormetazepam
Severity: Moderate
Ketamine and Lormetazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lormetazepam adds to the sedative effects of ketamine and may increase the risk of respiratory depression and psychomotor impairment. The combination may also attenuate ketamine emergence phenomena.
What this interaction means in plain words
Ketamine and Lormetazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A potentiation and NMDA antagonism.
What to do
Monitor sedation and respiration, and reduce doses as needed. Ensure airway support is available when ketamine is given at anesthetic doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketamine
Frequently asked questions
Can I take Ketamine with Lormetazepam?
MediHelp rates the interaction as moderate. Ketamine and Lormetazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lormetazepam adds to the sedative effects of ketamine and may increase the risk of respiratory depression and psychomotor impairment. The combination may also attenuate ketamine emergence phenomena.
How serious is the interaction between Ketamine and Lormetazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiration, and reduce doses as needed. Ensure airway support is available when ketamine is given at anesthetic doses.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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