Drug interactions
Ketamine + Lumacaftor / ivacaftor
Severity: Minor
Ketamine and Lumacaftor / ivacaftor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor is an inducer and ivacaftor an inhibitor of enzymes involved in ketamine metabolism, including CYP2B6, CYP2C9 and CYP3A4. The net effect on ketamine exposure is unpredictable, and efficacy or sedation may differ from expectations.
What this interaction means in plain words
Ketamine and Lumacaftor / ivacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Mixed induction (lumacaftor) and inhibition (ivacaftor) of CYP2B6, CYP2C9 and CYP3A4 involved in ketamine clearance.
What to do
Titrate ketamine to clinical response and monitor for reduced effect or excess sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketamine
Frequently asked questions
Can I take Ketamine with Lumacaftor / ivacaftor?
MediHelp rates the interaction as minor. Ketamine and Lumacaftor / ivacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lumacaftor is an inducer and ivacaftor an inhibitor of enzymes involved in ketamine metabolism, including CYP2B6, CYP2C9 and CYP3A4. The net effect on ketamine exposure is unpredictable, and efficacy or sedation may differ from expectations.
How serious is the interaction between Ketamine and Lumacaftor / ivacaftor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate ketamine to clinical response and monitor for reduced effect or excess sedation.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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