Drug interactions
Ketamine + Meprobamate
Severity: Moderate
Ketamine and Meprobamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meprobamate is a sedative anxiolytic, and combined use with ketamine can increase drowsiness and the risk of respiratory depression.
What this interaction means in plain words
Ketamine and Meprobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression.
What to do
Monitor sedation and respiration and reduce doses if needed. Avoid alcohol and other depressants alongside.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketamine
Frequently asked questions
Can I take Ketamine with Meprobamate?
MediHelp rates the interaction as moderate. Ketamine and Meprobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meprobamate is a sedative anxiolytic, and combined use with ketamine can increase drowsiness and the risk of respiratory depression.
How serious is the interaction between Ketamine and Meprobamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiration and reduce doses if needed. Avoid alcohol and other depressants alongside.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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