Drug interactions
Ketamine + Orphenadrine
Severity: Moderate
Ketamine and Orphenadrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orphenadrine is a sedating, anticholinergic muscle relaxant. With ketamine it may increase drowsiness, confusion and psychomotor impairment.
What this interaction means in plain words
Ketamine and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and anticholinergic effects.
What to do
Monitor sedation and mental status, particularly in older adults. Reduce doses if confusion or oversedation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketamine
Frequently asked questions
Can I take Ketamine with Orphenadrine?
MediHelp rates the interaction as moderate. Ketamine and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orphenadrine is a sedating, anticholinergic muscle relaxant. With ketamine it may increase drowsiness, confusion and psychomotor impairment.
How serious is the interaction between Ketamine and Orphenadrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and mental status, particularly in older adults. Reduce doses if confusion or oversedation develops.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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