Drug interactions
Ketamine + Quazepam
Severity: Moderate
Ketamine and Quazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quazepam is a long-acting benzodiazepine hypnotic, and its sedative effect adds to that of ketamine. This can increase drowsiness, impair psychomotor function and, in higher doses, depress breathing.
What this interaction means in plain words
Ketamine and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A potentiation and NMDA receptor antagonism.
What to do
Use reduced ketamine doses when titrating and monitor sedation and respiratory function. Counsel outpatients about impaired alertness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketamine
Frequently asked questions
Can I take Ketamine with Quazepam?
MediHelp rates the interaction as moderate. Ketamine and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quazepam is a long-acting benzodiazepine hypnotic, and its sedative effect adds to that of ketamine. This can increase drowsiness, impair psychomotor function and, in higher doses, depress breathing.
How serious is the interaction between Ketamine and Quazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use reduced ketamine doses when titrating and monitor sedation and respiratory function. Counsel outpatients about impaired alertness.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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