Drug interactions
Ketamine + Zotepine
Severity: Moderate
Ketamine and Zotepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zotepine is a sedating antipsychotic that adds to ketamine's CNS depression. It also lowers the seizure threshold and may cause hypotension or QT prolongation.
What this interaction means in plain words
Ketamine and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, with zotepine contributing alpha-blockade and seizure-threshold lowering.
What to do
Monitor sedation, blood pressure and ECG where indicated, and titrate ketamine cautiously. Use lower initial doses in vulnerable patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketamine
Frequently asked questions
Can I take Ketamine with Zotepine?
MediHelp rates the interaction as moderate. Ketamine and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zotepine is a sedating antipsychotic that adds to ketamine's CNS depression. It also lowers the seizure threshold and may cause hypotension or QT prolongation.
How serious is the interaction between Ketamine and Zotepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure and ECG where indicated, and titrate ketamine cautiously. Use lower initial doses in vulnerable patients.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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