Drug interactions
Ketorolac + Latanoprostene bunod
Severity: Minor
Ketorolac and Latanoprostene bunod: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic or ophthalmic NSAIDs may alter the intraocular pressure response to prostaglandin analogues because they inhibit prostaglandin synthesis. Published findings are inconsistent, and systemic exposure to the eye drop is small.
What this interaction means in plain words
Ketorolac and Latanoprostene bunod have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible pharmacodynamic interference of NSAID prostaglandin synthesis inhibition with prostaglandin-mediated aqueous outflow; not firmly established.
What to do
Check intraocular pressure at routine follow-up if ketorolac is used for a prolonged period. No dose change is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Frequently asked questions
Can I take Ketorolac with Latanoprostene bunod?
MediHelp rates the interaction as minor. Ketorolac and Latanoprostene bunod have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic or ophthalmic NSAIDs may alter the intraocular pressure response to prostaglandin analogues because they inhibit prostaglandin synthesis. Published findings are inconsistent, and systemic exposure to the eye drop is small.
How serious is the interaction between Ketorolac and Latanoprostene bunod?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check intraocular pressure at routine follow-up if ketorolac is used for a prolonged period. No dose change is usually needed.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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