Drug interactions
Ketorolac + Meclofenamic acid
Severity: Contraindicated
Ketorolac and Meclofenamic acid: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining ketorolac with another NSAID such as meclofenamate raises the risk of gastrointestinal ulceration and bleeding, renal impairment and bleeding from platelet inhibition. There is no added efficacy to offset this risk.
What this interaction means in plain words
Ketorolac and Meclofenamic acid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ketorolac belongs to Musculoskeletal; Meclofenamic acid belongs to Musculoskeletal.
Why it happens
Additive cyclooxygenase inhibition and prostaglandin suppression from two NSAIDs.
What to do
Do not use together; stop the other NSAID before starting ketorolac. Use a non-NSAID analgesic if extra pain control is needed.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Meclofenamic acid
Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Frequently asked questions
Can I take Ketorolac with Meclofenamic acid?
MediHelp rates the interaction as contraindicated. Ketorolac and Meclofenamic acid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining ketorolac with another NSAID such as meclofenamate raises the risk of gastrointestinal ulceration and bleeding, renal impairment and bleeding from platelet inhibition. There is no added efficacy to offset this risk.
How serious is the interaction between Ketorolac and Meclofenamic acid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; stop the other NSAID before starting ketorolac. Use a non-NSAID analgesic if extra pain control is needed.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Aceclofenac, Acemetacin. The full list is on the Meclofenamic acid page.
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