Drug interactions
Ketorolac + Mycophenolate
Severity: Moderate
Ketorolac and Mycophenolate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac and the glucuronide metabolite of mycophenolic acid may compete for renal tubular secretion, which could raise exposure to either. Both drugs also carry gastrointestinal and renal toxicity concerns.
What this interaction means in plain words
Ketorolac and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for renal tubular secretion by organic anion transporters between ketorolac and mycophenolic acid glucuronide.
What to do
Monitor renal function, blood counts and GI symptoms when used together. Limit ketorolac to the shortest course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Frequently asked questions
Can I take Ketorolac with Mycophenolate?
MediHelp rates the interaction as moderate. Ketorolac and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketorolac and the glucuronide metabolite of mycophenolic acid may compete for renal tubular secretion, which could raise exposure to either. Both drugs also carry gastrointestinal and renal toxicity concerns.
How serious is the interaction between Ketorolac and Mycophenolate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, blood counts and GI symptoms when used together. Limit ketorolac to the shortest course.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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