Drug interactions
Ketorolac + Nefazodone
Severity: Moderate
Ketorolac and Nefazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone inhibits serotonin reuptake, which can impair platelet aggregation. Together with ketorolac, the risk of bleeding, notably upper gastrointestinal bleeding, may be higher, though nefazodone's serotonergic effect is weaker than SSRIs.
What this interaction means in plain words
Ketorolac and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive platelet dysfunction from serotonin reuptake inhibition and COX-1 inhibition, plus NSAID mucosal injury.
What to do
Monitor for GI bleeding and consider gastroprotection in at-risk patients. Keep ketorolac duration short.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Frequently asked questions
Can I take Ketorolac with Nefazodone?
MediHelp rates the interaction as moderate. Ketorolac and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone inhibits serotonin reuptake, which can impair platelet aggregation. Together with ketorolac, the risk of bleeding, notably upper gastrointestinal bleeding, may be higher, though nefazodone's serotonergic effect is weaker than SSRIs.
How serious is the interaction between Ketorolac and Nefazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI bleeding and consider gastroprotection in at-risk patients. Keep ketorolac duration short.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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