Drug interactions
Ketorolac + Norepinephrine
Severity: Moderate
Ketorolac and Norepinephrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Norepinephrine is used in critically ill patients with compromised renal perfusion, where adding ketorolac may worsen kidney injury. The potassium effects of the two agents are small and opposing.
What this interaction means in plain words
Ketorolac and Norepinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of vasodilatory renal prostaglandins combined with norepinephrine-induced renal vasoconstriction reduces renal perfusion.
What to do
Avoid ketorolac in patients on vasopressors or with hemodynamic instability, and monitor urine output and creatinine if unavoidable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Frequently asked questions
Can I take Ketorolac with Norepinephrine?
MediHelp rates the interaction as moderate. Ketorolac and Norepinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Norepinephrine is used in critically ill patients with compromised renal perfusion, where adding ketorolac may worsen kidney injury. The potassium effects of the two agents are small and opposing.
How serious is the interaction between Ketorolac and Norepinephrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ketorolac in patients on vasopressors or with hemodynamic instability, and monitor urine output and creatinine if unavoidable.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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