Drug interactions
Ketorolac + Parecoxib
Severity: Contraindicated
Ketorolac and Parecoxib: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parecoxib is converted to valdecoxib, a COX-2 inhibitor, and combining it with ketorolac duplicates NSAID therapy. This raises the risk of renal injury, gastrointestinal complications and cardiovascular events, and ketorolac is contraindicated with other NSAIDs.
What this interaction means in plain words
Ketorolac and Parecoxib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive cyclooxygenase inhibition causing renal prostaglandin reduction, GI injury and thrombotic risk.
What to do
Do not use together. Use one NSAID at a time and choose a non-NSAID analgesic such as paracetamol if more analgesia is needed.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ketorolac and Parecoxib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Frequently asked questions
Can I take Ketorolac with Parecoxib?
MediHelp rates the interaction as contraindicated. Ketorolac and Parecoxib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Parecoxib is converted to valdecoxib, a COX-2 inhibitor, and combining it with ketorolac duplicates NSAID therapy. This raises the risk of renal injury, gastrointestinal complications and cardiovascular events, and ketorolac is contraindicated with other NSAIDs.
How serious is the interaction between Ketorolac and Parecoxib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Use one NSAID at a time and choose a non-NSAID analgesic such as paracetamol if more analgesia is needed.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
