Drug interactions
Ketorolac + Perindopril
Severity: Major
Ketorolac and Perindopril: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac can reduce the blood pressure control achieved with perindopril. Combined use raises the risk of acute kidney injury and hyperkalemia, and ketorolac is itself a potent renal-risk NSAID.
What this interaction means in plain words
Ketorolac and Perindopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ketorolac belongs to Musculoskeletal; Perindopril belongs to Cardiovascular.
Why it happens
NSAID inhibition of cyclooxygenase reduces vasodilatory renal prostaglandins, opposing ACE inhibitor effects and lowering glomerular filtration pressure.
What to do
Avoid in volume-depleted or renally impaired patients. If used, keep the course very short, ensure hydration and check creatinine, potassium and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Frequently asked questions
Can I take Ketorolac with Perindopril?
MediHelp rates the interaction as major. Ketorolac and Perindopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ketorolac can reduce the blood pressure control achieved with perindopril. Combined use raises the risk of acute kidney injury and hyperkalemia, and ketorolac is itself a potent renal-risk NSAID.
How serious is the interaction between Ketorolac and Perindopril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in volume-depleted or renally impaired patients. If used, keep the course very short, ensure hydration and check creatinine, potassium and blood pressure.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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