Drug interactions
Ketorolac + Prazosin
Severity: Minor
Ketorolac and Prazosin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the antihypertensive effect of various blood pressure medicines, and prazosin may be affected to a limited extent. The effect is generally modest and variable.
What this interaction means in plain words
Ketorolac and Prazosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ketorolac belongs to Musculoskeletal; Prazosin belongs to Genitourinary.
Why it happens
NSAID inhibition of vasodilatory prostaglandins and sodium and fluid retention may offset alpha-1 blockade.
What to do
Check blood pressure when ketorolac is added, especially if used for more than a few days, and adjust prazosin if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Other interactions of Prazosin
- Alfuzosin + Prazosin Major
- Amifostine + Prazosin Major
- Avanafil + Prazosin Major
- Doxazosin + Prazosin Major
- Dutasteride-tamsulosin + Prazosin Major
- Phenoxybenzamine + Prazosin Major
Frequently asked questions
Can I take Ketorolac with Prazosin?
MediHelp rates the interaction as minor. Ketorolac and Prazosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs can reduce the antihypertensive effect of various blood pressure medicines, and prazosin may be affected to a limited extent. The effect is generally modest and variable.
How serious is the interaction between Ketorolac and Prazosin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood pressure when ketorolac is added, especially if used for more than a few days, and adjust prazosin if control worsens.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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