Drug interactions
Ketorolac + Propranolol
Severity: Moderate
Ketorolac and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can weaken the antihypertensive effect of beta-blockers, and the effect is more evident with prolonged use. Blood pressure control may deteriorate, and ketorolac may also affect renal function.
What this interaction means in plain words
Ketorolac and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketorolac belongs to Musculoskeletal; Propranolol belongs to Cardiovascular.
Why it happens
NSAID suppression of renal and vascular prostaglandins causes sodium and water retention and vasoconstriction, counteracting beta-blocker effects.
What to do
Monitor blood pressure during co-use and limit ketorolac to the shortest course; adjust the antihypertensive regimen if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Frequently asked questions
Can I take Ketorolac with Propranolol?
MediHelp rates the interaction as moderate. Ketorolac and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can weaken the antihypertensive effect of beta-blockers, and the effect is more evident with prolonged use. Blood pressure control may deteriorate, and ketorolac may also affect renal function.
How serious is the interaction between Ketorolac and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during co-use and limit ketorolac to the shortest course; adjust the antihypertensive regimen if control is lost.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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