Drug interactions
Ketorolac + Quinapril
Severity: Major
Ketorolac and Quinapril: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the blood pressure lowering effect of ACE inhibitors and impair renal function when combined with them. Risk is greater in elderly, volume-depleted or renally impaired patients, and ketorolac is a potent nephrotoxic NSAID. Hyperkalemia may also occur.
What this interaction means in plain words
Ketorolac and Quinapril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
NSAIDs inhibit vasodilatory renal prostaglandins, reducing glomerular perfusion while ACE inhibition removes efferent arteriolar tone, and they also counter antihypertensive effects.
What to do
Avoid the combination where possible, especially in volume depletion or renal impairment, and keep any ketorolac course short. Monitor blood pressure, serum creatinine and potassium, and ensure adequate hydration.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Frequently asked questions
Can I take Ketorolac with Quinapril?
MediHelp rates the interaction as major. Ketorolac and Quinapril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs can blunt the blood pressure lowering effect of ACE inhibitors and impair renal function when combined with them. Risk is greater in elderly, volume-depleted or renally impaired patients, and ketorolac is a potent nephrotoxic NSAID. Hyperkalemia may also occur.
How serious is the interaction between Ketorolac and Quinapril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, especially in volume depletion or renal impairment, and keep any ketorolac course short. Monitor blood pressure, serum creatinine and potassium, and ensure adequate hydration.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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