Drug interactions
Ketorolac + Reishi
Severity: Moderate
Ketorolac and Reishi: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Reishi mushroom has reported antiplatelet activity in laboratory and limited human data. Combined with ketorolac, which impairs platelet function and irritates the gut lining, bleeding risk may be increased. Clinical evidence is sparse.
What this interaction means in plain words
Ketorolac and Reishi can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive antiplatelet effects; the herbal effect is not well characterized.
What to do
Ask patients about herbal use and advise stopping reishi while on ketorolac. Monitor for bruising, melena or other bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Frequently asked questions
Can I take Ketorolac with Reishi?
MediHelp rates the interaction as moderate. Ketorolac and Reishi can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Reishi mushroom has reported antiplatelet activity in laboratory and limited human data. Combined with ketorolac, which impairs platelet function and irritates the gut lining, bleeding risk may be increased. Clinical evidence is sparse.
How serious is the interaction between Ketorolac and Reishi?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask patients about herbal use and advise stopping reishi while on ketorolac. Monitor for bruising, melena or other bleeding.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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