Drug interactions
Ketorolac + Rivastigmine
Severity: Moderate
Ketorolac and Rivastigmine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cholinesterase inhibitors increase gastric acid secretion and may raise the risk of ulceration and gastrointestinal bleeding, particularly when combined with NSAIDs such as ketorolac. The risk is higher in older patients and those with a prior ulcer history.
What this interaction means in plain words
Ketorolac and Rivastigmine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketorolac belongs to Musculoskeletal; Rivastigmine belongs to Central Nervous System.
Why it happens
Cholinergic stimulation of gastric acid secretion adds to NSAID-induced mucosal injury and prostaglandin depletion.
What to do
Limit ketorolac to the shortest possible course, consider gastroprotection with a proton pump inhibitor, and monitor for dyspepsia, melena or anemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Other interactions of Rivastigmine
Frequently asked questions
Can I take Ketorolac with Rivastigmine?
MediHelp rates the interaction as moderate. Ketorolac and Rivastigmine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cholinesterase inhibitors increase gastric acid secretion and may raise the risk of ulceration and gastrointestinal bleeding, particularly when combined with NSAIDs such as ketorolac. The risk is higher in older patients and those with a prior ulcer history.
How serious is the interaction between Ketorolac and Rivastigmine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit ketorolac to the shortest possible course, consider gastroprotection with a proton pump inhibitor, and monitor for dyspepsia, melena or anemia.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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