Drug interactions
Ketorolac + Sodium picosulfate / magnesium oxide / anhydrous citric acid
Severity: Moderate
Ketorolac and Sodium picosulfate / magnesium oxide / anhydrous citric acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This bowel preparation causes fluid loss and electrolyte shifts. Ketorolac can reduce renal perfusion in a volume-depleted patient, so acute kidney injury becomes more likely.
What this interaction means in plain words
Ketorolac and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Preparation-induced volume depletion plus NSAID inhibition of renal prostaglandins reduces renal blood flow.
What to do
Avoid ketorolac and other NSAIDs around the bowel preparation, especially in elderly or renally impaired patients. Ensure hydration and check renal function and electrolytes if used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Frequently asked questions
Can I take Ketorolac with Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates the interaction as moderate. Ketorolac and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. This bowel preparation causes fluid loss and electrolyte shifts. Ketorolac can reduce renal perfusion in a volume-depleted patient, so acute kidney injury becomes more likely.
How serious is the interaction between Ketorolac and Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ketorolac and other NSAIDs around the bowel preparation, especially in elderly or renally impaired patients. Ensure hydration and check renal function and electrolytes if used.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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