Drug interactions
Ketorolac + Telmisartan-amlodipine
Severity: Major
Ketorolac and Telmisartan-amlodipine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac can reduce the antihypertensive effect of telmisartan and, together with an angiotensin receptor blocker, may precipitate acute kidney injury, especially in older or volume-depleted patients. Ketorolac carries particular renal risk, and hyperkalemia may also occur.
What this interaction means in plain words
Ketorolac and Telmisartan-amlodipine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ketorolac belongs to Musculoskeletal; Telmisartan-amlodipine belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal perfusion, which compounds angiotensin II receptor blockade effects on glomerular filtration and potassium handling.
What to do
Avoid in volume depletion or renal impairment and prefer another analgesic. If used, keep to the shortest course allowed and monitor creatinine, potassium and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Frequently asked questions
Can I take Ketorolac with Telmisartan-amlodipine?
MediHelp rates the interaction as major. Ketorolac and Telmisartan-amlodipine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ketorolac can reduce the antihypertensive effect of telmisartan and, together with an angiotensin receptor blocker, may precipitate acute kidney injury, especially in older or volume-depleted patients. Ketorolac carries particular renal risk, and hyperkalemia may also occur.
How serious is the interaction between Ketorolac and Telmisartan-amlodipine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in volume depletion or renal impairment and prefer another analgesic. If used, keep to the shortest course allowed and monitor creatinine, potassium and blood pressure.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
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