Drug interactions
Ketorolac + Tenofovir disoproxil
Severity: Major
Ketorolac and Tenofovir disoproxil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir is cleared by glomerular filtration and tubular secretion and can itself cause kidney injury. Ketorolac is a potent NSAID with a notable risk of renal impairment, so combined use may precipitate acute kidney injury.
What this interaction means in plain words
Ketorolac and Tenofovir disoproxil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity, with NSAID-induced reduction in renal perfusion that may raise tenofovir exposure.
What to do
Avoid ketorolac in patients on tenofovir where possible and use paracetamol or another alternative. If it is essential, give the shortest course and monitor serum creatinine closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Frequently asked questions
Can I take Ketorolac with Tenofovir disoproxil?
MediHelp rates the interaction as major. Ketorolac and Tenofovir disoproxil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tenofovir is cleared by glomerular filtration and tubular secretion and can itself cause kidney injury. Ketorolac is a potent NSAID with a notable risk of renal impairment, so combined use may precipitate acute kidney injury.
How serious is the interaction between Ketorolac and Tenofovir disoproxil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ketorolac in patients on tenofovir where possible and use paracetamol or another alternative. If it is essential, give the shortest course and monitor serum creatinine closely.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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