Drug interactions
Ketorolac + Ticarcillin
Severity: Moderate
Ketorolac and Ticarcillin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticarcillin can impair platelet function and cause bleeding at high doses, and ketorolac also inhibits platelets. Both are renally secreted so levels may rise slightly. The combination may increase bleeding tendency.
What this interaction means in plain words
Ketorolac and Ticarcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive platelet dysfunction plus possible competition for renal tubular secretion.
What to do
Monitor for bleeding and renal function when combined. Consider a non-NSAID analgesic in patients at higher bleeding risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Frequently asked questions
Can I take Ketorolac with Ticarcillin?
MediHelp rates the interaction as moderate. Ketorolac and Ticarcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ticarcillin can impair platelet function and cause bleeding at high doses, and ketorolac also inhibits platelets. Both are renally secreted so levels may rise slightly. The combination may increase bleeding tendency.
How serious is the interaction between Ketorolac and Ticarcillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and renal function when combined. Consider a non-NSAID analgesic in patients at higher bleeding risk.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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