Drug interactions
Ketorolac + Triamcinolone acetonide injectable
Severity: Moderate
Ketorolac and Triamcinolone acetonide injectable: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids and NSAIDs each raise the risk of gastric irritation, ulceration and bleeding, and the risk is higher together. Ketorolac is particularly ulcerogenic. A single local triamcinolone injection carries less risk than systemic therapy.
What this interaction means in plain words
Ketorolac and Triamcinolone acetonide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive gastrointestinal mucosal injury from prostaglandin inhibition and corticosteroid effects.
What to do
Keep ketorolac to the shortest course and consider a proton pump inhibitor in at-risk patients. Watch for gastrointestinal bleeding symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Frequently asked questions
Can I take Ketorolac with Triamcinolone acetonide injectable?
MediHelp rates the interaction as moderate. Ketorolac and Triamcinolone acetonide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids and NSAIDs each raise the risk of gastric irritation, ulceration and bleeding, and the risk is higher together. Ketorolac is particularly ulcerogenic. A single local triamcinolone injection carries less risk than systemic therapy.
How serious is the interaction between Ketorolac and Triamcinolone acetonide injectable?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep ketorolac to the shortest course and consider a proton pump inhibitor in at-risk patients. Watch for gastrointestinal bleeding symptoms.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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