Drug interactions
Ketorolac intranasal + Meloxicam
Severity: Contraindicated
Ketorolac intranasal and Meloxicam: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meloxicam and intranasal ketorolac together duplicate NSAID effects and increase the risk of gastrointestinal bleeding, renal impairment and cardiovascular events. The systemically absorbed ketorolac carries a label restriction against other NSAIDs.
What this interaction means in plain words
Ketorolac intranasal and Meloxicam are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive cyclooxygenase inhibition producing additive gastrointestinal, renal, platelet and cardiovascular toxicity.
What to do
Do not use together; choose one NSAID. Use paracetamol or another non-NSAID if more analgesia is needed.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Meloxicam
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
- Amiloride + Meloxicam Major
Frequently asked questions
Can I take Ketorolac intranasal with Meloxicam?
MediHelp rates the interaction as contraindicated. Ketorolac intranasal and Meloxicam are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Meloxicam and intranasal ketorolac together duplicate NSAID effects and increase the risk of gastrointestinal bleeding, renal impairment and cardiovascular events. The systemically absorbed ketorolac carries a label restriction against other NSAIDs.
How serious is the interaction between Ketorolac intranasal and Meloxicam?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose one NSAID. Use paracetamol or another non-NSAID if more analgesia is needed.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac, Aceclofenac, Acemetacin. The full list is on the Meloxicam page.
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